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Monday, October 19, 2026

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@convequity

Convequity on X

Why we exited $CRSP and kept $TEM AlphaFold solved the backend of the problem — predicting a protein’s 3D structure from its sequence. The harder frontend problem remains: knowing which protein or pathway is actually worth targeting. Most complex diseases are still poorly understood at the causal level. That distinction matters. The next real breakthroughs look more likely to come from AI-native groups that treat large-scale compute as the primary engine, in the same way OpenAI and Anthropic approached language before the ChatGPT moment. Public investors may only get clean access later via secondaries or IPOs. CRISPR sits on the earlier-generation side of that divide. Tempus is closer to the compute-and-data native side — building models while assembling a genuine clinical data moat. That is why one was exited and the other retained.
@evantindell

Evan Tindell on X

Finally got a chance to go through the $UMG earnings... Obviously, a disappointment on revenue growth and margins, which saw the stock drop like 20%. Subscription revenue was 6.7% organically, and the street was looking for >9%. So, a big miss. Still, I think things should improve. Apple, Spotify, Amazon, and YouTube music have all raised prices this year, and a portion of that will go to UMG. CFO Matt Ellis said on the call that these prices and "better market share to start the third quarter" make them "cautiously optimistic" (really sticking his neck out there!!) that growth will improve in H2 of 2026. Interestingly, Warner Music $WMG managed to grow revenue 12% in CC and adjusted OIBDA by 24%, so clearly this is a UMG-only problem, at least for this quarter. $UMG trades at 14x earnings on a NTM basis now... this seems pretty reasonable if not downright cheap for a company that has grown EBIT from EUR 1b in 2019 to around 2b today (11% organic EBITDA CAGR). We own this through Bollore, which currently has an NAV of just above 11 EUR by my calculation vs a last price of under 4 EUR. Notably, JPM thinks new AI tiers in Spotify and Apple Music will drive ARPU growth of 300 bps per year. Their price target was 48 EUR prior to the recent earnings release...

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Semtech Analyst Day Review

Semtech raised Q3 guidance and targets $3.2 billion of fiscal 2030 revenue, excluding upside from its AI data-center optical and copper…

SMTC $13B
CV's Substack 14 clicks

Is The Market Turning The Page?

CoreWeave’s debt and equity price action is framed as a wake-up call for investors amid a broader market discussion.

CRWV $34B
WHAT ARE WE DOING? “Contrarians At The Gate” 54 clicks

Constellation: Stars Aligning?

Constellation Brands trades near $127 at roughly 11x next-twelve-month EV/EBIT, with recent business results offsetting concerns over…

STZ $22B
TSOH Investment Research 28 clicks

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